Tranquis is an early-stage biotechnology company founded on cutting-edge neuro-immunology research from the laboratory of Prof. Edgar G. Engleman at Stanford University, which shows that altered metabolism of myeloid immune cells underlies a variety of central nervous system (CNS) disorders, including Amyotrophic Lateral Sclerosis, Parkinson’s Disease, Alzheimer’s Disease, and age-related neuropathology.
Driven by fellow co-founder, Dr. Khoa D. Nguyen, the laboratory has made major advances in the field by engineering a unique R&D platform to identify abnormal immuno-neurological pathways via gene expression data in diseased humans and subsequently validate them in proprietary animal models.
In several models of CNS diseases, the company's lead compound potently suppresses abnormal activity of myeloid immune cells, resulting marked reduction in neuropathology as well as an extension of lifespan.
Tranquis is being built on a strong and proprietary underlying scientific rationale that neuropathology associated with multiple CNS disorders results from abnormal activation of myeloid immune cells.
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